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There is limited information on the safety of memantine treatment in patients with moderate to severe Alzheimer's disease with serious co-morbidities, as these patients were excluded from clinical trials.

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Patients must alert their physicians if they are taking any medications (prescription or non-prescription) within the last 14 days, especially NMDA-receptor antagonists such as amantedine, or any of the following medications: cimetidine, ranitidine, procainamide, quinidine, quinine, hydrochlorothiazide (or any combination with hydrochlorothiazide), anticholinergics (substances generally used to treat movement disorders such as Parkinson's disease or intestinal cramps), dopaminergic agonists (substances such as L-dopa, bromocriptine), ketamine and dextromethorphan (e.

Memantine is often used in combination with cholinesterase inhibitors; the combination of memantine and donepezil was found to offer greater benefit in cognitive, functional, neuropsychiatric, and global outcomes than donepezil alone in a 6-month placebo-controlled trial of patients with moderate to severe AD.

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This allows the dose to affect the binding of memantine without affecting its removal from the site of action and allowing for increased potency with minimal side affects.

What is Memantine LEK and what is it used for?

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It may be difficult to tell if Alzheimer's drugs are helping, because their effect is usually modest.

For more information about treatment with Memantine LEK, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.

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In the two studies of mild to moderate disease, patients on Ebixa had less severe symptoms after 24 weeks, as measured on the global and cognitive scores.

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It is acetylcholine that is badly affected in Alzheimer's patients.

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ChEIs are associated with a well-defined adverse effect profile; gastrointestinal problems such as nausea, diarrhea, and less commonly vomiting, are the primary adverse events observed early in therapy (Table 1).

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Malaz Boustani, Jorge Rodriguez, Ruth C Brown, and Cornelius L Katona, Efficacy of Memantine on Behavioral and Psychological Symptoms Related to Dementia: A Systematic Meta-Analysis.

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In a double-blind, randomized and placebo-controlled trial, adjuvant memantine improved symptoms in inpatients suffering from refractory obsessive-compulsive disorders (OCD)".

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